Working With Your 23andMe Raw Data
How to download the raw genotype file, convert it to VCF against a reference, lift it to GRCh38, impute, score, and know which conclusions the array can and cannot support.
Tag: imputation
6 posts
How to Download Your DNA Data and Turn It Into Something You Can Analyze
A step-by-step guide to exporting raw genotype files from Ancestry, 23andMe, and MyHeritage, converting them to a reference-correct VCF, lifting to GRCh38, imputing, and understanding what an array file can and cannot tell you.
What Genotyping Costs, From $40 Arrays to $600 Genomes
A breakdown of real 2026 prices for SNP arrays, exomes, and whole-genome sequencing, what each one measures, and the storage, compute, and interpretation costs that follow.
What DNA Upload Sites Can Tell You, and What They Cannot
A technical answer to which genetic sites are worth uploading raw DNA to, what the array file contains, and how to run the same analyses yourself with plink, bcftools, and an imputation server.
What to Do With Your DNA.Land Upload Now That the Site Is Gone
DNA.Land stopped accepting uploads and shut down its reports. This guide shows how to take the same raw genotype file, convert it to VCF, impute it, annotate it, and decide which remaining upload sites are worth your data.
How to Work With Your tellmeGen Raw Data
A practical pipeline for turning a tellmeGen raw data export into a build-verified VCF, running quality control, annotating it, and understanding what a genotyping array can and cannot tell you.