What WES Data Is and How to Work With It
Whole exome sequencing covers roughly 1-2% of the genome at high depth. What the files contain, which tools we use, and where the coverage gaps are.
Tag: exome
8 posts
Whole Exome Sequencing: What It Covers, What It Misses, and How to Analyze It
How exome capture works, the analysis pipeline for your own FASTQs, and the failure modes that decide whether an exome is the right assay.
How to Analyze Your Own Exome Sequencing Data
A working pipeline for whole-exome data from FASTQ to VCF, with the filters that matter and the places where exome capture loses to a whole genome.
Is Exome Sequencing Worth It, or Should You Just Sequence the Genome?
What whole exome sequencing covers, where capture fails, and how to check the quality of an exome you already own.
Exome Panel, Whole Exome, or Whole Genome: What to Sequence and Why
A gene panel is a subset of an exome, and an exome is about 1.5% of a genome. Here's how the three differ in coverage, cost, file sizes, and what you can re-analyze later.
What an exome test costs, and what you get for the money
A line-by-line breakdown of exome sequencing prices in 2026: raw-data-only versus clinical CLIA reports, what drives the spread, and what the files look like when they land.
What WES Testing Is and When It Falls Short
Whole exome sequencing reads the ~1-2% of your genome that codes for protein. What it finds, what it silently misses, and how to read the files yourself.
What Whole Exome Sequencing Costs in 2026
A breakdown of WES pricing: research-grade versus CLIA-clinical, what drives the per-sample cost, how trios are billed, and why the sequencing is the cheap part of the project.